Posts Tagged History of Science

Innumeracy and Overconfidence in Medical Training

Most medical doctors, having ten or more years of education, can’t do simple statistics calculations that they were surely able to do, at least for a week or so, as college freshmen. Their education has let them down, along with us, their patients. That education leaves many doctors unquestioning, unscientific, and terribly overconfident.

A disturbing lack of doubt has plagued medicine for thousands of years. Galen, at the time of Marcus Aurelius, wrote, “It is I, and I alone, who has revealed the true path of medicine.” Galen disdained empiricism. Why bother with experiments and observations when you own the truth. Galen’s scientific reasoning sounds oddly similar to modern junk science armed with abundant confirming evidence but no interest in falsification. Galen had plenty of confirming evidence: “All who drink of this treatment recover in a short time, except those whom it does not help, who all die. It is obvious, therefore, that it fails only in incurable cases.”

Galen was still at work 1500 years later when Voltaire wrote that the art of medicine consisted of entertaining the patient while nature takes its course. One of Voltaire’s novels also described a patient who had survived despite the best efforts of his doctors. Galen was around when George Washington died after five pints of bloodletting, a practice promoted up to the early 1900s by prominent physicians like Austin Flint.

CodmanBut surely medicine was mostly scientific by the 1900s, right? Actually, 20th century medicine was dragged kicking and screaming to scientific methodology. In the early 1900’s Ernest Amory Codman of Massachusetts General proposed keeping track of patients and rating hospitals according to patient outcome. He suggested that a doctor’s reputation and social status were poor measures of a patient’s chance of survival. He wanted the track records of doctors and hospitals to be made public, allowing healthcare consumers to choose suppliers based on statistics. For this, and for his harsh criticism of those who scoffed at his ideas, Codman was tossed out of Mass General, lost his post at Harvard, and was suspended from the Massachusetts Medical Society. Public outcry brought Codman back into medicine, and much of his “end results system” was put in place.

20th century medicine also fought hard against the concept of controlled trials. Austin Bradford Hill introduced the concept to medicine in the mid 1920s. But in the mid 1950s Dr. Archie Cochrane was still fighting valiantly against what he called the God Complex in medicine, which was basically the ghost of Galen; no one should question the authority of a physician. Cochrane wrote that far too much of medicine lacked any semblance of scientific validation and knowing what treatments actually worked. He wrote that the medical establishment was hostile the idea of controlled trials. Cochrane fought this into the 1970s, authoring Effectiveness and Efficiency: Random Reflections on Health Services in 1972.

Doctors aren’t naturally arrogant. The God Complex is passed passed along during the long years of an MD’s education and internship. That education includes rights of passage in an old boys’ club that thinks sleep deprivation builds character in interns, and that female med students should make tea for the boys. Once on the other side, tolerance of archaic norms in the MD culture seems less offensive to the inductee, who comes to accept the system. And the business of medicine, the way it’s regulated, and its control by insurance firms, pushes MDs to view patients as a job to be done cost-effectively. Medical arrogance is in a sense encouraged by recovering patients who might see doctors as savior figures.

As Daniel Kahneman wrote, “generally, it is considered a weakness and a sign of vulnerability for clinicians to appear unsure.” Medical overconfidence is encouraged by patients’ preference for doctors who communicate certainties, even when uncertainty stems from technological limitations, not from doctors’ subject knowledge. MDs should be made conscious of such dynamics and strive to resist inflating their self importance. As Allan Berger wrote in Academic Medicine in 2002, “we are but an instrument of healing, not its source.”

Many in medical education are aware of these issues. The calls for medical education reform – both content and methodology – are desperate, but they are eerily similar to those found in a 1924 JAMA article, Current Criticism of Medical Education.

Covid19 exemplifies the aspect of medical education I find most vile. Doctors can’t do elementary statistics and probability, and their cultural overconfidence renders them unaware of how critically they need that missing skill.

A 1978 study, brought to the mainstream by psychologists like Kahnemann and Tversky, showed how few doctors know the meaning of a positive diagnostic test result. More specifically, they’re ignorant of the relationship between the sensitivity and specificity (true positive and true negative rates) of a test and the probability that a patient who tested positive has the disease. This lack of knowledge has real consequences In certain situations, particularly when the base rate of the disease in a population is low. The resulting probability judgements can be wrong by factors of hundreds or thousands.

In the 1978 study (Cascells et. al.) doctors and medical students at Harvard teaching hospitals were given a diagnostic challenge. “If a test to detect a disease whose prevalence is 1 out of 1,000 has a false positive rate of 5 percent, what is the chance that a person found to have a positive result actually has the disease?” As described, the true positive rate of the diagnostic test is 95%. This is a classic conditional-probability quiz from the second week of a probability class. Being right requires a), knowing Bayes Theorem, and b), being able to multiply and divide. Not being confidently wrong requires only one thing: scientific humility – the realization that all you know might be less than all there is to know. The correct answer is 2% – there’s a 2% likelihood the patient has the disease. The most common response, by far, in the 1978 study was 95%, which is wrong by 4750%. Only 18% of doctors and med students gave the correct response. The study’s authors observed that in the group tested, “formal decision analysis was almost entirely unknown and even common-sense reasoning about the interpretation of laboratory data was uncommon.”

As mentioned above, this story was heavily publicized in the 80s. It was widely discussed by engineering teams, reliability departments, quality assurance groups and math departments. But did it impact medical curricula, problem-based learning, diagnostics training, or any other aspect of the way med students were taught? One might have thought yes, if for no reason than to avoid criticism by less prestigious professions having either the relevant knowledge of probability or the epistemic humility to recognize that the right answer might be far different from the obvious one.

Similar surveys were done in 1984 (David M Eddy) and in 2003 (Kahan, Paltiel) with similar results. In 2013, Manrai and Bhatia repeated Cascells’ 1978 survey with the exact same wording, getting trivially better results. 23% answered correctly. They suggesting that medical education “could benefit from increased focus on statistical inference.” That was 35 years after Cascells, during which, the phenomenon was popularized by the likes of Daniel Kahneman, from the perspective of base-rate neglect, by Philip Tetlock, from the perspective of overconfidence in forecasting, and by David Epstein, from the perspective of the tyranny of specialization.

Over the past decade, I’ve asked the Cascells question to doctors I’ve known or met, where I didn’t think it would get me thrown out of the office or booted from a party. My results were somewhat worse. Of about 50 MDs, four answered correctly or were aware that they’d need to look up the formula but knew that it was much less than 95%. One was an optometrist, one a career ER doc, one an allergist-immunologist, and one a female surgeon – all over 50 years old, incidentally.

Despite the efforts of a few radicals in the Accreditation Council for Graduate Medical Education and some post-Flexnerian reformers, medical education remains, as Jonathan Bush points out in Tell Me Where It Hurts, basically a 2000 year old subject-based and lecture-based model developed at a time when only the instructor had access to a book. Despite those reformers, basic science has actually diminished in recent decades, leaving many physicians with less of a grasp of scientific methodology than that held by Ernest Codman in 1915. Medical curriculum guardians, for the love of God, get over your stodgy selves and replace the calculus badge with applied probability and statistical inference from diagnostics. Place it later in the curriculum later than pre-med, and weave it into some of that flipped-classroom, problem-based learning you advertise.

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Paul Feyerabend, The Worst Enemy of Science

“How easy it is to lead people by the nose in a rational way.”

A similarly named post I wrote on Paul Feyerabend seven years ago turned out to be my most popular post by far. Seeing it referenced in a few places has made me cringe, and made me face the fact that I failed to make my point. I’ll try to correct that here. I don’t remotely agree with the paper in Nature that called Feyerabend the worst enemy of science, nor do I side with the postmodernists that idolize him. I do find him to be one of the most provocative thinkers of the 20th century, brash, brilliant, and sometimes full of crap.

Feyerabend opened his profound Against Method by telling us to always remember that what he writes in the book does not reflect any deep convictions of his, but that he intends “merely show how easy it is to lead people by the nose in a rational way.” I.e., he was more telling us what he thought we needed to hear than what he necessarily believed. In his autobiography he wrote that for Against Method he had used older material but had “replaced moderate passages with more outrageous ones.” Those using and abusing Feyerabend today have certainly forgot what this provocateur, who called himself an entertainer, told us always to remember about him in his writings.

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Any who think Feyerabend frivolous should examine the scientific rigor in his analysis of Galileo’s work. Any who find him to be an enemy of science should actually read Against Method instead of reading about him, as quotes pulled from it can be highly misleading as to his intent. My communications with some of his friends after he died in 1994 suggest that while he initially enjoyed ruffling so many feathers with Against Method, he became angered and ultimately depressed over both critical reactions against it and some of the audiences that made weapons of it. In 1991 he wrote, “I often wished I had never written that fucking book.”

I encountered Against Method searching through a library’s card catalog seeking an authority on the scientific method. I learned from Feyerabend that no set of methodological rules fits the great advances and discoveries in science. It’s obvious once you think about it. Pick a specific scientific method – say the hypothetico-deductive model – or any set of rules, and Feyerabend will name a scientific discovery that would not have occurred had the scientist, from Galileo to Feynman, followed that method, or any other.

Part of Feyerabend’s program was to challenge the positivist notion that in real science, empiricism trumps theory. Galileo’s genius, for Feyerabend, was allowing theory to dominate observation. In Dialogue Galileo wrote:

Nor can I ever sufficiently admire the outstanding acumen of those who have taken hold of this opinion and accepted it as true: they have, through sheer force of intellect, done such violence to their own senses as to prefer what reason told them over that which sensible experience plainly showed them to be the contrary.

For Feyerabend, against Popper and the logical positivists of the mid 1900’s, Galileo’s case exemplified a need to grant theory priority over evidence. This didn’t sit well with empiricist leanings of the the post-war western world. It didn’t set well with most scientists or philosophers. Sociologists and literature departments loved it. It became fuel for fire of relativism sweeping America in the 70’s and 80’s and for the 1990’s social constructivists eager to demote science to just another literary genre.

PKF2But in context, and in the spheres for which Against Method was written, many people – including Feyerabend’s peers from 1970 Berkeley, with whom I’ve had many conversations on the topic, conclude that the book’s goading style was a typical Feyerabendian corrective provocation to that era’s positivistic dogma.

Feyerabend distrusts the orthodoxy of social practices of what Thomas Kuhn termed “normal science” – what scientific institutions do in their laboratories. Unlike their friend Imre Lakatos, Feyerabend distrusts any rule-based scientific method at all. Instead, Feyerabend praises the scientific innovation and individual creativity. For Feyerabend science in the mid 1900’s had fallen prey to the “tyranny of tightly-knit, highly corroborated, and gracelessly presented theoretical systems.” What would he say if alive today?

As with everything in the philosophy of science in the late 20th century, some of the disagreement between Feyerabend, Kuhn, Popper and Lakatos revolved around miscommunication and sloppy use of language. The best known case of this was Kuhn’s inconsistent use of the term paradigm. But they all (perhaps least so Lakatos) talked past each other by failing to differentiate different meanings of the word science, including:

  1. An approach or set of rules and methods for inquiry about nature
  2. A body of knowledge about nature
  3. In institution, culture or community of scientists, including academic, government and corporate

Kuhn and Feyerabend in particular vacillating between meaning science as a set of methods and science as an institution. Feyerabend certainly was referring to an institution when he said that science was a threat to democracy and that there must be “a separation of state and science just as there is a separation between state and religious institutions.” Along these lines Feyerabend thought that modern institutional science resembles more the church of Galileo’s day than it resembles Galileo.

On the matter of state control of science, Feyerabend went further than Eisenhower did in his “military industrial complex” speech, even with the understanding that what Eisenhower was describing was a military-academic-industrial complex. Eisenhower worried that a government contract with a university “becomes virtually a substitute for intellectual curiosity.” Feyerabend took this worry further, writing that university research requires conforming to orthodoxy and “a willingness to subordinate one’s ideas to those of a team leader.” Feyerabend disparaged Kuhn’s normal science as dogmatic drudgery that stifles scientific creativity.

A second area of apparent miscommunication about the history/philosophy of science in the mid 1900’s was the descriptive/normative distinction. John Heilbron, who was Kuhn’s grad student when Kuhn wrote Structure of Scientific Revolutions, told me that Kuhn absolutely despised Popper, not merely as a professional rival. Kuhn wanted to destroy Popper’s notion that scientists discard theories on finding disconfirming evidence. But Popper was describing ideally performed science; his intent was clearly normative. Kuhn’s work, said Heilbron (who doesn’t share my admiration for Feyerabend), was intended as normative only for historians of science, not for scientists. True, Kuhn felt that it was pointless to try to distinguish the “is” from the “ought” in science, but this does not mean he thought they were the same thing.

As with Kuhn’s use of paradigm, Feyerabend’s use of the term science risks equivocation. He drifts between methodology and institution to suit the needs of his argument. At times he seems to build a straw man of science in which science insists it creates facts as opposed to building models. Then again, on this matter (fact/truth vs. models as the claims of science) he seems to be more right about the science of 2019 than he was about the science of 1975.

While heavily indebted to Popper, Feyerabend, like Kuhn, grew hostile to Popper’s ideas of demarcation and falsification: “let us look at the standards of the Popperian school, which are still being taken seriously in the more backward regions of knowledge.” He eventually expanded his criticism of Popper’s idea of theory falsification to a categorical rejection of Popper’s demarcation theories and of Popper’s critical rationalism in general. Now from the perspective of half a century later, a good bit of the tension between Popper and both Feyerabend and Kuhn and between Kuhn and Feyerabend seems to have been largely semantic.

For me, Feyerabend seems most relevant today through his examination of science as a threat to democracy. He now seems right in ways that even he didn’t anticipate. He thought it a threat mostly in that science (as an institution) held complete control over what is deemed scientifically important for society. In contrast, people as individuals or small competing groups, historically have chosen what counts as being socially valuable. In this sense science bullied the citizen, thought Feyerabend. Today I think we see a more extreme example of bullying, in the case of global warming for example, in which government and institutionalized scientists are deciding not only what is important as a scientific agenda but what is important as energy policy and social agenda. Likewise the role that neuroscience plays in primary education tends to get too much of the spotlight in the complex social issues of how education should be conducted. One recalls Lakatos’ concern against Kuhn’s confidence in the authority of “communities.” Lakatos had been imprisoned by the Nazis for revisionism. Through that experience he saw Kuhn’s “assent of the relevant community” as not much of a virtue if that community has excessive political power and demands that individual scientists subordinate their ideas to it.

As a tiny tribute to Feyerabend, about whom I’ve noted caution is due in removal of his quotes from their context, I’ll honor his provocative spirit by listing some of my favorite quotes, removed from context, to invite misinterpretation and misappropriation.

“The similarities between science and myth are indeed astonishing.”

“The church at the time of Galileo was much more faithful to reason than Galileo himself, and also took into consideration the ethical and social consequences of Galileo’s doctrine. Its verdict against Galileo was rational and just, and revisionism can be legitimized solely for motives of political opportunism.”

“All methodologies have their limitations and the only ‘rule’ that survives is ‘anything goes’.”

“Revolutions have transformed not only the practices their initiators wanted to change buy the very principles by means of which… they carried out the change.”

“Kuhn’s masterpiece played a decisive role. It led to new ideas, Unfortunately it also led to lots of trash.”

“First-world science is one science among many.”

“Progress has always been achieved by probing well-entrenched and well-founded forms of life with unpopular and unfounded values. This is how man gradually freed himself from fear and from the tyranny of unexamined systems.”

“Research in large institutes is not guided by Truth and Reason but by the most rewarding fashion, and the great minds of today increasingly turn to where the money is — which means military matters.”

“The separation of state and church must be complemented by the separation of state and science, that most recent, most aggressive, and most dogmatic religious institution.”

“Without a constant misuse of language, there cannot be any discovery, any progress.”

 

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Photos of Paul Feyerabend courtesy of Grazia Borrini-Feyerabend

 

 

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Was Thomas Kuhn Right about Anything?

William Storage – 9/1/2016
Visiting Scholar, UC Berkeley History of Science

Fifty years ago Thomas Kuhn’s Structures of Scientific Revolution armed sociologists of science, constructionists, and truth-relativists with five decades of cliche about the political and social dimensions of theory choice and scientific progress’s inherent irrationality. Science has bias, cries the social-justice warrior. Despite actually being a scientist – or at least holding a PhD in Physics from Harvard, Kuhn isn’t well received by scientists and science writers. They generally venture into history and philosophy of science as conceived by Karl Popper, the champion of the falsification model of scientific progress.

Kuhn saw Popper’s description of science as a self-congratulatory idealization for researchers. That is, no scientific theory is ever discarded on the first  observation conflicting with the theory’s predictions. All theories have anomalous data. Dropping heliocentrism because of anomalies in Mercury’s orbit was unthinkable, especially when, as Kuhn stressed, no better model was available at the time. Einstein said that if Eddington’s experiment would have not shown bending of light rays around the sun, “I would have had to pity our dear Lord. The theory is correct all the same.”

Kuhn was wrong about a great many details. Despite the exaggeration of scientific detachment by Popper and the proponents of rational-reconstruction, Kuhn’s model of scientists’ dogmatic commitment to their theories is valid only in novel cases. Even the Copernican revolution is overstated. Once the telescope was in common use and the phases of Venus were confirmed, the philosophical edifices of geocentrism crumbled rapidly in natural philosophy. As Joachim Vadianus observed, seemingly predicting the scientific revolution, sometimes experience really can be demonstrative.

Kuhn seems to have cherry-picked historical cases of the gap between normal and revolutionary science. Some revolutions – DNA and the expanding universe for example – proceeded with no crisis and no battle to the death between the stalwarts and the upstarts. Kuhn’s concept of incommensurabilty also can’t withstand scrutiny. It is true that Einstein and Newton meant very different things when they used the word “mass.” But Einstein understood exactly what Newton meant by mass, because Einstein had grown up a Newtonian. And if brought forth, Newton, while he never could have conceived of Einsteinian mass, would have had no trouble understanding Einstein’s concept of mass from the perspective of general relativity, had Einstein explained it to him.

Likewise, Kuhn’s language about how scientists working in different paradigms truly, not merely metaphorically, “live in different worlds” should go the way of mood rings and lava lamps. Most charitably, we might chalk this up to Kuhn’s terminological sloppiness. He uses “success terms” like “live” and “see,” where he likely means “experience visually” or “perceive.” Kuhn describes two observers, both witnessing the same phenomenon, but “one sees oxygen, where another sees dephlogisticated air” (emphasis mine). That is, Kuhn confuses the descriptions of visual experiences with the actual experiences of observation – to the delight of Steven ShapinBruno Latour and the cultural relativists.

Finally, Kuhn’s notion that theories completely control observation is just as wrong as scientists’ belief that their experimental observations are free of theoretical influence and that their theories are independent of their values.

Despite these flaws, I think Kuhn was on to something. He was right, at least partly, about the indoctrination of scientists into a paradigm discouraging skepticism about their research program. What Wolfgang Lerche of CERN called “the Stanford propaganda machine” for string theory is a great example. Kuhn was especially right in describing science education as presenting science as a cumulative enterprise, relegating failed hypotheses to the footnotes. Einstein built on Newton in the sense that he added more explanations about the same phenomena; but in no way was Newton preserved within Einstein. Failing to see an Einsteinian revolution in any sense just seems akin to a proclamation of the infallibility not of science but of scientists. I was surprised to see this attitude in Stephen Weinberg’s recent To Explain the World. Despite excellent and accessible coverage of the emergence of science, he presents a strictly cumulative model of science. While Weinberg only ever mentions Kuhn in footnotes, he seems to be denying that Kuhn was ever right about anything.

For example, in describing general relativity, Weinberg says in 1919 the Times of London reported that Newton had been shown to be wrong. Weinberg says, “This was a mistake. Newton’s theory can be regarded as an approximation to Einstein’s – one that becomes increasingly valid for objects moving at velocities much less than that of light. Not only does Einstein’s theory not disprove Newton’s, relativity explains why Newton’s theory works when it does work.”

This seems a very cagey way of saying that Einstein disproved Newton’s theory. Newtonian dynamics is not an approximation of general relativity, despite their making similar predictions for mid-sized objects at small relative speeds. Kuhn’s point that Einstein and Newton had fundamentally different conceptions of mass is relevant here. Newton’s explanation of his Rule III clearly stresses universality. Newton emphasized the universal applicability of his theory because he could imagine no reason for its being limited by anything in nature. Given that, Einstein should, in terms of explanatory power, be seen as overturning – not extending – Newton, despite the accuracy of Newton for worldly physics.

Weinberg insists that Einstein is continuous with Newton in all respects. But when Eddington showed that light waves from distant stars bent around the sun during the eclipse of 1918, Einstein disproved Newtonian mechanics. Newton’s laws of gravitation predict that gravity would have no effect on light because photons do not have mass. When Einstein showed otherwise he disproved Newton outright, despite the retained utility of Newton for small values of v/c. This is no insult to Newton. Einstein certainly can be viewed as continuous with Newton in the sense of getting scientific work done. But Einsteinian mechanics do not extend Newton’s; they contradict them. This isn’t merely a metaphysical consideration; it has powerful explanatory consequences. In principle, Newton’s understanding of nature was wrong and it gave wrong predictions. Einstein’s appears to be wrong as well; but we don’t yet have a viable alternative. And that – retaining a known-flawed theory when nothing better is on the table – is, by the way, another thing Kuhn was right about.

 


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“A few years ago I happened to meet Kuhn at a scientific meeting and complained to him about the nonsense that had been attached to his name. He reacted angrily. In a voice loud enough to be heard by everyone in the hall, he shouted, ‘One thing you have to understand. I am not a Kuhnian.’” – Freeman Dyson, The Sun, The Genome, and The Internet: Tools of Scientific Revolutions

 

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Feynman as Philosopher

When a scientist is accused of scientism, the common response is a rant against philosophy charging that philosophers of science don’t know how science works.  For color, you can appeal to the authority of Richard Feynman:

“Philosophy of science is about as useful to scientists as ornithology is to birds.” – Richard Feynman

But Feynman never said that. If you have evidence, please post it here. Evidence. We’re scientists, right?

Feynman’s hostility to philosophy is often reported, but without historical basis. His comment about Spinoza’s propositions not being confirmable or falsifiable deal specifically with Spinoza and metaphysics, not epistemology. Feynman actually seems to have had a keen interest in epistemology and philosophy of science.

People cite a handful of other Feynman moments to show his hostility to philosophy of science. In his 1966 National Science Teachers Association lecture, he uses the term “philosophy of science” when he points out how Francis Bacon’s empiricism does not capture the nature of science. Not do textbooks about scientific method, he says. Beyond this sort of thing I find little evidence of Feynman’s anti-philosophy stance.

But I find substantial evidence of Feynman as philosopher of science. For example, his thoughts on multiple derivability of natural laws and his discussion of robustness of theory show him to be a philosophical methodologist. In “The Character of Physical Law”, Feynman is in line with philosophers of science of his day:

“So the first thing we have to accept is that even in mathematics you can start in different places. If all these various theorems are interconnected by reasoning there is no real way to say ‘these are the most fundamental axioms’, because if you were told something different instead you could also run the reasoning the other way.”

Further, much of his 1966 NSTA lecture deals with the relationship between theory, observation and making explanations. A tape of that talk was my first exposure to Feynman, by the way. I’ll never forget the story of him asking his father why the ball rolled to the back of wagon as the wagon lurched forward. His dad’s answer: “That, nobody knows… It’s called inertia.”

Via a twitter post, I just learned of a video clip of Feynman discussing theory choice – a staple of philosophy of science – and theory revision. Now he doesn’t use the language you’d find in Kuhn, Popper, or Lakatos; but he covers a bit of the same ground. In it, he describes two theories with deeply different ideas behind them, both of which give equally valid predictions. He says,

“Suppose we have two such theories. How are we going to describe which one is right? No way. Not by science. Because they both agree with experiment to the same extent…

“However, for psychological reasons, in order to get new theories, these two theories are very far from equivalent, because one gives a man different ideas than the other. By putting the theory in a certain kind of framework you get an idea what to change.”

Not by science alone, can theory choice be made, says the scientist Feynman. Philosopher of science Thomas Kuhn caught hell for saying the same. Feynman clearly weighs explanatory power higher than predictive success in the various criteria for theory choice. He then alludes to the shut-up-and-calculate practitioners of quantum mechanics, indicating that this position makes for weak science. He does this with a tale of competing Mayan astronomy theories.

He imagines a Mayan astronomer who had a mathematical model that perfectly predicted full moons and eclipses, but with no concept of space, spheres or orbits. Feynman then supposes that a young man says to the astronomer, “I have an idea – maybe those things are going around and they’re balls of rock out there, and we can calculate how they move.” The astronomer asks the young man how accurately can his theory predict eclipses. The young man said his theory wasn’t developed sufficiently to predict that yet. The astronomer boasts, “we can calculate eclipses more accurately than you can with your model, so you must not pay any attention to your idea because obviously the mathematical scheme is better.”

Feynman again shows he values a theory’s explanatory power over predictive success. He concludes:

“So it is a problem as to whether or not to worry about philosophies behind ideas.”

So much for Feynman’s aversion to philosophy of science.

 

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Thanks to Ardian Tola @rdntola for finding the Feynman lecture video.

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My Grandfather’s Science

Velociraptor by Ben TownsendThe pace of technology is breathtaking. For that reason we’re tempted to believe our own time to be the best of times, the worst, the most wise and most foolish, most hopeful and most desperate, etc. And so we insist that our own science and technology be received, for better or worse, in the superlative degree of comparison only. For technology this may be valid. For science, technology’s foundation, perhaps not. Some perspective is humbling.

This may not be your grandfather’s Buick – or his science. It contemplates my grandfather’s science – the mind-blowing range of scientific progress during his life. It may dwarf the scientific progress of the next century. In terms of altering the way we view ourselves and our relationship to the world, the first half of the 20th century dramatically outpaced the second half.

My grandfather was born in 1898 and lived through nine decades of the 20th century. That is, he saw the first manned airplane flight and the first man on the moon. He also witnessed scientific discoveries that literally changed worldviews.

My grandfather was fascinated by the Mount Wilson observatory. The reason was the role it had played in one of the several scientific discoveries of his youth that rocked not only scientist’s view of nature but everyone’s view of themselves and of reality. These were cosmological blockbusters with metaphysical side effects.

When my grandfather was a teen, the universe was the Milky Way. The Milky Way was all the stars we could see; and it included some cloudy areas called nebulae. Edwin Hubble studied these nebulae when he arrived at Mount Wilson in 1919. Using the brand new Hooker Telescope at Mt. Wilson, Hubble located Cepheid variables in several nebulae. Cepheids are the “standard candle” stars that allow astronomers to measure their distance from earth. Hubble studied the Andromeda Nebula, as it was then known. He concluded that this nebula was not glowing gas in the Milky Way, but was a separate galaxy far away. Really far.

In one leap, the universe grew from our little galaxy to about 100,000,000 light years across. That huge number had been previously argued but was ruled out in the “Great Debate” between Shapley and Curtis in April 1920. To earlier arguments that Andromeda was a galaxy, Harvard University’s Harlow Shapley had convinced most scientists that Andromeda was just some glowing gas. Assuming galaxies of the same size, Shapley noted that Andromeda would have to be 100 million light years away to occupy the angular distance we observe. Most scientists simply could not fathom a universe that big. By 1925 Hubble and his telescope on Mt. Wilson had fixed all that.

Over the next few decades Hubble’s observations showed galaxies far more distant than Andromeda – millions of them. Stranger yet, they showed that the universe was expanding, something that even Albert Einstein did not want to accept.

The big expanding universe so impressed my grandfather that he put Mt. Wilson on his bucket list. His first trip to California in 1981 included a visit there. Nothing known to us today comes close to the cosmological, philosophical and psychological weight of learning, as a steady-state Milky Way believer, that there was a beginning of time and that space is stretching. Well, nothing except the chaotic inflation theory also proposed during my grandfather’s life. The Hubble-era universe grew by three orders of magnitude. Inflation theory asks us to accept hundreds of orders of magnitude more. Popular media doesn’t push chaotic inflation, despite its mind-blowing implications. This could stem from our lacking the high school math necessary to grasp inflation theory’s staggering numbers. The Big Bang and Cosmic Inflation will be tough acts for the 21st century to follow.

Another conceptual hurdle for the early 20th century was evolution. Yes, everyone knows that Darwin wrote in the mid-1800s; but many are unaware of the low status the theory of evolution had in biology at the turn of the century. Biologists accepted that life derived from a common origin, but the mechanism Darwin proposed was impossible. In the late 1800’s the thermodynamic calculations of Lord Kelvin (William Thomson, an old-earth creationist) conflicted with Darwin’s model of the emergence of biological diversity. Thomson’s 50-million year old earth couldn’t begin to accommodate prokaryotes, velociraptors and hominids. Additionally, Darwin didn’t have a discreet (Mendelian) theory of inheritance to allow retention of advantageous traits. The “blending theory of inheritance” then in vogue let such features regress toward the previous mean.

Darwinian evolution was rescued in the early 1900s by the discovery of radioactive decay. In 1913 Arthur Holmes, using radioactive decay as a marker, showed that certain rocks on earth were two billion years old. Evolution now had time to work. At about the same time, Mendel’s 1865 paper was rediscovered. Following Mendel, William Bateson proposed the term genetics in 1903 and the word gene in 1909 to describe the mechanism of inheritance. By 1920, Darwinian evolution and the genetic theory were two sides of the same coin. In just over a decade, 20th century thinkers let scientific knowledge change their self-image and their relationship to the world. The universe was big, the earth was old, and apes were our cousins.

Another “quantum leap” our recent ancestors had to make was quantum physics. It’s odd that we say “quantum leap” to mean a big jump. Quanta are extremely small, as are the quantum jumps of electrons. Max Planck kicked off the concept of quanta in 1900. It got a big boost in 1905 from Einstein. Everyone knows that Einstein revolutionized science with the idea of relativity in 1905. But that same year – in his spare time – he also published papers on Brownian motion and the photoelectric effect (illuminated metals give off electrons). In explaining Brownian motion, Einstein argued that atoms are real, not just a convenient model for chemistry calculations as was commonly held. In some ways the last topic, photoelectric effect, was the most profound. Like many had done with atoms Planck considered quanta as a convenient fiction. Einstein’s work on the photoelectric effect, for which he later got the Nobel Prize, made quanta real. This was the start of quantum physics.

Relativity told us that light bends and that matter warps space. This was weird stuff, but at least it spared most of the previous century’s theories – things like the atomic theory of matter and electromagnetism. Quantum physics uprooted everything. It overturned the conceptual framework of previous science and even took a bite out of basic rationality. It told us that reality at small scales is nothing like what we perceive. It said that everything, including light perhaps even time and space – is ultimately discreet, not continuous; nature is digital. Future events can affect the past and the ball can pass through the wall. Beyond the weird stuff, quantum physics makes accurate and practical predictions. It also makes your iPhone work. My grandfather didn’t have one, but his transistor radio was quantum-powered.

Technology’s current heyday is built on the science breakthroughs of a century earlier. If that seems like a stretch consider the following. Planck invented the quantum in 1900, Einstein the photon in 1903, and Von Lieben the vacuum tube in 1906. Schwarzschild predicted black holes in 1916, a few years before Hubble found foreign galaxies. Georges Lemaitre proposed a Big Bang in 1927, Dirac antimatter in 1928, and Chadwick the atomic nucleus in 1932. Ruska invented the electron microscope the following year, two years before plastic was invented. In 1942 Fermi tested controlled nuclear reactions. Avery identified DNA as the carrier of genes in 1944; Crick and Watson found the double helix in 1953. In 1958 Kilby invented the integrated circuit. Two years later Maiman had a working laser, just before the Soviets put a man in orbit. Gell-Man invented quarks in 1964. Recombinant DNA, neutron stars, and interplanetary probes soon followed. My grandfather, born in the 1800s, lived to see all of this, along with personal computers, cell phones and GPS. He liked science and so should you, your kids and your school board.

While recent decades have seen marvelous inventions and cool gadgets, conceptual breakthroughs like those my grandfather witnessed are increasingly rare. It’s time to pay the fiddler. Science education is in crisis. Less than half of New York City’s high schools offer a class in physics and only a third of US high school students take a physics class. Women, African Americans and Latinos are grossly underrepresented in the hard sciences.

Political and social science don’t count. Learn physics, kids. Then teach it to your parents.

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Multidisciplinary

In college, fellow cave explorer Ron Simmons found that the harnesses made for rock climbing performed very poorly underground. The cave environment shredded the seams of the harnesses from which we hung hundreds of feet off the ground in the underworld of remote southern Mexico. The conflicting goals of minimizing equipment expenses and avoiding death from equipment failure awakened our innovative spirit.

Bill Storage

We wondered if we could build a better caving harness ourselves. Having access to UVA’s Instron testing machine Ron hand-stitched some webbing junctions to compare the tensile characteristics of nylon and polyester topstitching thread. His experiments showed too much variation from irregularities in his stitching, so he bought a Singer industrial sewing machine. At that time Ron had no idea how sew. But he mastered the machine and built fabulous caving harnesses. Ron later developed and manufactured hardware for ropework and specialized gear for cave diving. Curiosity about earth’s last great exploration frontier propelled our cross-disciplinary innovation. Curiosity, imagination and restlessness drive multidisciplinarity.

Soon we all owned sewing machines, making not only harnesses but wetsuits and nylon clothing. We wrote mapping programs to reduce our survey data and invented loop-closure algorithms to optimally distribute errors across a 40-mile cave survey. We learned geomorphology to predict the locations of yet undiscovered caves. Ron was unhappy with the flimsy commercial photo strobe equipment we used underground so he learned metalworking and the electrical circuitry needed to develop the indestructible strobe equipment with which he shot the above photo of me.

Fellow caver Bill Stone pushed multidisciplinarity further. Unhappy with conventional scuba gear for underwater caving, Bill invented a multiple-redundant-processor, gas-scrubbing rebreather apparatus that allowed 12-hour dives on a tiny “pony tank” oxygen cylinder. This device evolved into the Cis-Lunar Primary Life Support System later praised by the Apollo 11 crew. Bill’s firm, Stone Aerospace, later developed autonomous underwater vehicles under NASA Astrobiology contracts, for which I conducted probabilistic risk analyses. If there is life beneath the ice of Jupiter’s moon Europa, we’ll need robots like this to find it.

Artemis

My years as a cave explorer and a decade as a systems engineer in aerospace left me comfortable crossing disciplinary boundaries. I enjoy testing the tools of one domain on the problems of another. The Multidisciplinarian is a hobby blog where I experiment with that approach. I’ve tried to use the perspective of History of Science on current issues in Technology (e.g.) and the tools of Science and Philosophy on Business Management and Politics (e.g.).

Terms like interdisciplinary and multidisciplinary get a fair bit of press in tech circles. Their usage speaks to the realization that while intense specialization and deep expertize are essential for research, they are the wrong tools for product design, knowledge transfer, addressing customer needs, and everything else related to society’s consumption of the fruits of research and invention.

These terms are generally shunned by academia for several reasons. One reason is the abuse of the terms in fringe social sciences of the 80s and 90s. Another is that the university system, since the time of Aristotle’s Lyceum, has consisted of silos in which specialists compete for top position. Academic status derives from research, and research usually means specialization. Academic turf protection and the research grant system also contribute. As Gina Kolata noted in a recent NY Times piece, the reward system of funding agencies discourages dialog between disciplines. Disappointing results in cancer research are often cited as an example of sectoral research silos impeding integrative problem solving.

Beside the many examples of silo inefficiencies, we have a long history of breakthroughs made possible by individuals who mastered several skills and integrated them. Galileo, Gutenberg, Franklin and Watt were not mere polymaths. They were polymaths who did something more powerful than putting specialists together in a room. They put ideas together in a mind.

On this view, specialization may be necessary to implement a solution but is insufficient for conceiving of that solution. Lockheed Martin does not design aircraft by putting aerodynamicists, propulsion experts, and stress analysts together in a think tank. It puts them together, along with countless other specialists, and a cadre of integrators, i.e., systems engineers, for whom excessive disciplinary specialization would be an obstacle. Bill Stone has deep knowledge in several sciences, but his ARTEMIS project, a prototype of a vehicle that could one day discover life beneath an ice-covered moon of Jupiter, succeeded because of his having learned to integrate and synthesize.

A famous example from another field is the case of the derivation of the double-helix model of DNA by Watson and Crick. Their advantage in the field, mostly regarded as a weakness before their discovery, was their failure – unlike all their rivals – to specialize in a discipline. This lack of specialization allowed them to move conceptually between disciplines, fusing separate ideas from Avery, Chargaff and Wilkins, thereby scooping front runner Linus Pauling.

Dev Patnaik, leader of Jump Associates, is a strong advocate of the conscious blending of different domains to discover opportunities that can’t be seen through a single lens. When I spoke with Dev at a recent innovation competition our conversation somehow drifted from refrigeration in Nairobi to Ludwig Wittgenstein. Realizing that, we shared a good laugh. Dev expresses pride for having hired MBA-sculptors, psychologist-filmmakers and the like. In a Fast Company piece, Dev suggested that beyond multidisciplinary teams, we need multidisciplinary people.

The silos that stifle innovation come in many forms, including company departments, academic disciplines, government agencies, and social institutions. The smarts needed to solve a problem are often at a great distance from the problem itself. Successful integration requires breaking down both institutional and epistemological barriers.

I recently overheard professor Olaf Groth speaking to a group of MBA students at Hult International Business School. Discussing the Internet of Things, Olaf told the group, “remember – innovation doesn’t go up, it goes across.” I’m not sure what context he had in mind, but it’s a great point regardless. The statement applies equally well to cognitive divides, academic disciplinary boundaries, and corporate silos.

Olaf’s statement reminded me of a very concrete example of a missed opportunity for cross-discipline, cross-division action at Gillette. Gillette acquired both Oral-B, the old-school toothbrush maker, and Braun, the electric appliance maker, in 1984. Gillette then acquired Duracell in 1996. But five years later, Gillette had not found a way into the lucrative battery-powered electric toothbrush market – despite having all the relevant technologies in house, but in different silos. They finally released the CrossAction (ironic name) brush in 2002; but it was inferior to well-established Colgate and P&G products. Innovation initiatives at Gillette were stymied by the usual suspects –  principal-agent, misuse of financial tools in evaluating new product lines, misuse of platform-based planning, and holding new products to the same metrics as established ones. All that plus the fact that the divisions weren’t encouraged to look across. The three units were adjacent in a list of divisions and product lines in Gillette’s Strategic Report.

Multidisciplinarity (or interdisciplinarity, if you prefer) clearly requires more than a simple combination of academic knowledge and professional skills. Innovation and solving new problems require integrating and synthesizing different repositories of knowledge to frame problems in a real-world context rather than through the lens of a single discipline. This shouldn’t be so hard. After all, we entered the world free of disciplinary boundaries, and we know that fervent curiosity can dissolve them.

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The average student emerges at the end of the Ph.D. program, already middle-aged, overspecialized, poorly prepared for the world outside, and almost unemployable except in a narrow area of specialization. Large numbers of students for whom the program is inappropriate are trapped in it, because the Ph.D. has become a union card required for entry into the scientific job market. – Freeman Dyson

Science is the organized skepticism in the reliability of expert opinion. – Richard Feynman

Curiosity is one of the permanent and certain characteristics of a vigorous intellect. – Samuel Johnson

The exhortation to defer to experts is underpinned by the premise that their specialist knowledge entitles them to a higher moral status than the rest of us. – Frank Furedi

It is a miracle that curiosity survives formal education. – Albert Einstein

An expert is one who knows more and more about less and less until he knows absolutely everything about nothing. – Nicholas Murray Butler

A specialist is someone who does everything else worse. – Ruggiero Ricci

 

Ron Simmons
Ron Simmons, 1954-2007

 

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Stop Orbit Change Denial Now

April 1, 2016.

Just like you, I grew up knowing that, unless we destroy it, the earth would  be around for another five billion years. At least I thought I knew we had a comfortable window to find a new home. That’s what the astronomical establishment led us to believe. Well it’s not true. There is a very real possibility that long before the sun goes red giant on us, instability of the multi-body gravitational dynamics at work in the solar system will wreak havoc. Some computer models show such deadly dynamism in as short as a few hundred millions years.

One outcome is that Jupiter will pull Mercury off course so that it will cross Venus’s orbit and collide with the earth. “To call this catastrophic is a gross understatement,” says Berkeley astronomer Ken Croswell. Gravitational instability might also hurl Mars from the solar system, thereby warping Earth’s orbit so badly that our planet will be ripped to shreds. If you can imagine nothing worse, hang on to your helmet. In another model, the earth itself is heaved out of orbit and we’re on a cosmic one-way journey into the blackness of interstellar space for eternity. Hasta la vista, baby.

Knowledge of the risk of orbit change isn’t new; awareness is another story. The knowledge goes right back to Isaac Newton. In 1687 Newton concluded that in a two-body system, each body attracts the other with a force (which we do not understand, but call gravity) that is proportional to the product of their masses and inversely proportional to the square of the distance between them. That is, he gave a mathematical justification for what Keppler had merely inferred from observing the movement of planets. Newton then proposed that every body in the universe attracts every other body according to the same rule. He called it the universal law of gravitation. Newton’s law predicted how bodies would behave if only gravitational forces acted upon them. This cannot be tested in the real world, as there are no such bodies. Bodies in the universe are also affected by electromagnetism and the nuclear forces. Thus no one can test Newton’s theory precisely.

Ignoring the other forces of nature, Newton’s law plus simple math allows us to predict the future position of a two-body system given their properties at a specific time. Newton also noted, in Book 3 of his Principia, that predicting the future of a three body system was an entirely different problem. Many set out solve the so-called three-body (or generalized n-body) problem. Finally, over two hundred years later, Henri Poincaré, after first wrongly believing he had worked it out – and forfeiting the prize offered by King Oscar of Sweden for a solution – gave mathematical evidence that there can be no analytical solution to the n-body problem. The problem is in the realm of what today is called chaos theory. Even with powerful computers, rounding errors in the numbers used to calculate future paths of planets prevent conclusive results. The butterfly effect takes hold. In a computer planetary model, changing the mass of Mercury by a billionth of a percent might mean the difference between it ultimately being pulled into the sun and it’s colliding with Venus.

Too many mainstream astronomers are utterly silent on the issue of potential earth orbit change. Given that the issue of instability has been known since Poincaré, why is academia silent on the matter. Even Carl Sagan, whom I trusted in my youth, seems party to the conspiracy. In Episode 9 of Cosmos, he told us:

“Some 5 billion years from now, there will be a last perfect day on Earth. Then the sun will slowly change and the earth will die. There is only so much hydrogen fuel in the sun, and when it’s almost all converted to helium the solar interior will continue its original collapse… life will be extinguished, the oceans will evaporate and boil, and gush away to space. The sun will become a bloated red giant star filling the sky, enveloping and devouring the planets Mercury and Venus, and probably the earth as well. The inner planets will be inside the sun. But perhaps by then our descendants will have ventured somewhere else.”

He goes on to explain that we are built of star stuff, dodging the whole matter of orbital instability. But there is simply no mechanistic predictability in the solar system to ensure the earth will still be orbiting when the sun goes red-giant. As astronomer Caleb Scharf says, “the notion of the clockwork nature of the heavens now counts as one of the greatest illusions of science.” Scharf is one of the bold scientists who’s broken with the military-industrial-astronomical complex to spread the truth about earth orbit change.

But for most astronomers, there is a clear denial of the potential of earth orbit change and the resulting doomsday; and this has to stop. Let’s stand with science. It’s time to expose orbit change deniers. Add your name to the list, and join the team to call them out, one by one.

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Can Science Survive?

galileo
In my last post I ended with the question of whether science in the pure sense can withstand science in the corporate, institutional, and academic senses. Here’s a bit more on the matter.

Ronald Reagan, pandering to a church group in Dallas, famously said about evolution, “Well, it is a theory. It is a scientific theory only.” (George Bush, often “quoted” as saying this, did not.) Reagan was likely ignorant of the distinction between two uses of the word, theory. On the street, “theory” means an unsettled conjecture. In science a theory – gravitation for example – is a body of ideas that explains observations and makes predictions. Reagan’s statement fueled years of appeals to teach creationism in public schools, using titles like creation science and intelligent design. While the push for creation science is usually pinned on southern evangelicals, it was UC Berkeley law professor Phillip E Johnson who brought us intelligent design.

Arkansas was a forerunner in mandating equal time for creation science. But its Act 590 of 1981 (Balanced Treatment for Creation-Science and Evolution-Science Act) was shut down a year later by McLean v. Arkansas Board of Education. Judge William Overton made philosophy of science proud with his set of demarcation criteria. Science, said Overton:

  • is guided by natural law
  • is explanatory by reference to natural law
  • is testable against the empirical world
  • holds tentative conclusions
  • is falsifiable

For earlier thoughts on each of Overton’s five points, see, respectively, Isaac Newton, Adelard of Bath, Francis Bacon, Thomas Huxley, and Karl Popper.

In the late 20th century, religious fundamentalists were just one facet of hostility toward science. Science was also under attack on the political and social fronts, as well an intellectual or epistemic front.

President Eisenhower, on leaving office in 1960, gave his famous “military industrial complex” speech warning of the “danger that public policy could itself become the captive of a scientific technological elite.” At about the same time the growing anti-establishment movements – perhaps centered around Vietnam war protests –  vilified science for selling out to corrupt politicians, military leaders and corporations. The ethics of science and scientists were under attack.

Also at the same time, independently, an intellectual critique of science emerged claiming that scientific knowledge necessarily contained hidden values and judgments not based in either objective observation (see Francis Bacon) or logical deduction (See Rene Descartes). French philosophers and literary critics Michel Foucault and Jacques Derrida argued – nontrivially in my view – that objectivity and value-neutrality simply cannot exist; all knowledge has embedded ideology and cultural bias. Sociologists of science ( the “strong program”) were quick to agree.

This intellectual opposition to the methodological validity of science, spurred by the political hostility to the content of science, ultimately erupted as the science wars of the 1990s. To many observers, two battles yielded a decisive victory for science against its critics. The first was publication of Higher Superstition by Gross and Levitt in 1994. The second was a hoax in which Alan Sokal submitted a paper claiming that quantum gravity was a social construct along with other postmodern nonsense to a journal of cultural studies. After it was accepted and published, Sokal revealed the hoax and wrote a book denouncing sociology of science and postmodernism.

Sadly, Sokal’s book, while full of entertaining examples of the worst of postmodern critique of science, really defeats only the most feeble of science’s enemies, revealing a poor grasp of some of the subtler and more valid criticism of science. For example, the postmodernists’ point that experimentation is not exactly the same thing as observation has real consequences, something that many earlier scientists themselves – like Robert Boyle and John Herschel – had wrestled with. Likewise, Higher Superstition, in my view, falls far below what we expect from Gross and Levitt. They deal Bruno Latour a well-deserved thrashing for claiming that science is a completely irrational process, and for the metaphysical conceit of holding that his own ideas on scientific behavior are fact while scientists’ claims about nature are not. But beyond that, Gross and Levitt reveal surprisingly poor knowledge of history and philosophy of science. They think Feyerabend is anti-science, they grossly misread Rorty, and waste time on a lot of strawmen.

Following closely  on the postmodern critique of science were the sociologists pursuing the social science of science. Their findings: it is not objectivity or method that delivers the outcome of science. In fact it is the interests of all scientists except social scientists that govern the output of scientific inquiry. This branch of Science and Technology Studies (STS), led by David Bloor at Edinburgh in the late 70s, overplayed both the underdetermination of theory by evidence and the concept of value-laden theories. These scientists also failed to see the irony of claiming a privileged position on the untenability of privileged positions in science. I.e., it is an absolute truth that there are no absolute truths.

While postmodern critique of science and facile politics in STC studies seem to be having a minor revival, the threats to real science from sociology, literary criticism and anthropology (I don’t mean that all sociology and anthropology are non-scientific) are small. But more subtle and possibly more ruinous threats to science may exist; and they come partly from within.

Modern threats to science seem more related to Eisenhower’s concerns than to the postmodernists. While Ike worried about the influence the US military had over corporations and universities (see the highly nuanced history of James Conant, Harvard President and chair of the National Defense Research Committee), Eisenhower’s concern dealt not with the validity of scientific knowledge but with the influence of values and biases on both the subjects of research and on the conclusions reached therein. Science, when biased enough, becomes bad science, even when scientists don’t fudge the data.

Pharmaceutical research is the present poster child of biased science. Accusations take the form of claims that GlaxoSmithKline knew that Helicobacter pylori caused ulcers – not stress and spicy food – but concealed that knowledge to preserve sales of the blockbuster drugs, Zantac and Tagamet. Analysis of those claims over the past twenty years shows them to be largely unsupported. But it seems naïve to deny that years of pharmaceutical companies’ mailings may have contributed to the premature dismissal by MDs and researchers of the possibility that bacteria could in fact thrive in the stomach’s acid environment. But while Big Pharma may have some tidying up to do, its opponents need to learn what a virus is and how vaccines work.

Pharmaceutical firms generally admit that bias, unconscious and of the selection and confirmation sort – motivated reasoning – is a problem. Amgen scientists recently tried to reproduce results considered landmarks in basic cancer research to study why clinical trials in oncology have such high failure rate. They reported in Nature that they were able to reproduce the original results in only six of 53 studies. A similar team at Bayer reported that only about 25% of published preclinical studies could be reproduced. That the big players publish analyses of bias in their own field suggests that the concept of self-correction in science is at least somewhat valid, even in cut-throat corporate science.

Some see another source of bad pharmaceutical science as the almost religious adherence to the 5% (+- 1.96 sigma) definition of statistical significance, probably traceable to RA Fisher’s 1926 The Arrangement of Field Experiments. The 5% false-positive probability criterion is arbitrary, but is institutionalized. It can be seen as a classic case of subjectivity being perceived as objectivity because of arbitrary precision. Repeat any experiment long enough and you’ll get statistically significant results within that experiment. Pharma firms now aim to prevent such bias by participating in a registration process that requires researchers to publish findings, good, bad or inconclusive.

Academic research should take note. As is often reported, the dependence of publishing on tenure and academic prestige has taken a toll (“publish or perish”). Publishers like dramatic and conclusive findings, so there’s a strong incentive to publish impressive results – too strong. Competitive pressure on 2nd tier publishers leads to their publishing poor or even fraudulent study results. Those publishers select lax reviewers, incapable of or unwilling to dispute authors. Karl Popper’s falsification model of scientific behavior, in this scenario, is a poor match for actual behavior in science. The situation has led to hoaxes like Sokal’s, but within – rather than across – disciplines. Publication of the nonsensical “Fuzzy”, Homogeneous Configurations by Marge Simpson and Edna Krabappel (cartoon character names) by the Journal of Computational Intelligence and Electronic Systems in 2014 is a popular example. Following Alan Sokal’s line of argument, should we declare the discipline of computational intelligence to be pseudoscience on this evidence?

Note that here we’re really using Bruno Latour’s definition of science – what scientists and related parties do with a body of knowledge in a network, rather than simply the body of knowledge. Should scientists be held responsible for what corporations and politicians do with their knowledge? It’s complicated. When does flawed science become bad science. It’s hard to draw the line; but does that mean no line needs to be drawn?

Environmental science, I would argue, is some of the worst science passing for genuine these days. Most of it exists to fill political and ideological roles. The Bush administration pressured scientists to suppress communications on climate change and to remove the terms “global warming” and “climate change” from publications. In 2005 Rick Piltz resigned from the  U.S. Climate Change Science Program claiming that Bush appointee Philip Cooney had personally altered US climate change documents to lessen the strength of their conclusions. In a later congressional hearing, Cooney confirmed having done this. Was this bad science, or just bad politics? Was it bad science for those whose conclusions had been altered not to blow the whistle?

The science of climate advocacy looks equally bad. Lack of scientific rigor in the IPCC is appalling – for reasons far deeper than the hockey stick debate. Given that the IPCC started with the assertion that climate change is anthropogenic and then sought confirming evidence, it is not surprising that the evidence it has accumulated supports the assertion. Compelling climate models, like that of Rick Muller at UC Berkeley, have since given strong support for anthropogenic warming. That gives great support for the anthropogenic warming hypothesis; but gives no support for the IPCC’s scientific practices. Unjustified belief, true or false, is not science.

Climate change advocates, many of whom are credentialed scientists, are particularly prone to a mixing bad science with bad philosophy, as when evidence for anthropogenic warming is presented as confirming the hypothesis that wind and solar power will reverse global warming. Stanford’s Mark Jacobson, a pernicious proponent of such activism, does immeasurable damage to his own stated cause with his descent into the renewables fantasy.

Finally, both major climate factions stoop to tying their entire positions to the proposition that climate change has been measured (or not). That is, both sides are in implicit agreement that if no climate change has occurred, then the whole matter of anthropogenic climate-change risk can be put to bed. As a risk man observing the risk vector’s probability/severity axes – and as someone who buys fire insurance though he has a brick house – I think our science dollars might be better spent on mitigation efforts that stand a chance of being effective rather than on 1) winning a debate about temperature change in recent years, or 2) appeasing romantic ideologues with “alternative” energy schemes.

Science survived Abe Lincoln (rain follows the plow), Ronald Reagan (evolution just a theory) and George Bush (coercion of scientists). It will survive Barack Obama (persecution of deniers) and Jerry Brown and Al Gore (science vs. pronouncements). It will survive big pharma, cold fusion, superluminal neutrinos, Mark Jacobson, Brian Greene, and the Stanford propaganda machine. Science will survive bad science because bad science is part of science, and always has been. As Paul Feyerabend noted, Galileo routinely used propaganda, unfair rhetoric, and arguments he knew were invalid to advance his worldview.

Theory on which no evidence can bear is religion. Theory that is indifferent to evidence is often politics. Granting Bloor, for sake of argument, that all theory is value-laden, and granting Kuhn, for sake of argument, that all observation is theory-laden, science still seems to have an uncanny knack for getting the world right. Planes fly, quantum tunneling makes DVD players work, and vaccines prevent polio. The self-corrective nature of science appears to withstand cranks, frauds, presidents, CEOs, generals and professors. As Carl Sagan Often said, science should withstand vigorous skepticism. Further, science requires skepticism and should welcome it, both from within and from irksome sociologists.

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the multidisciplinarian

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XKCD cartoon courtesy of xkcd.com

 

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The Trouble with Strings

Theoretical physicist Brian Greene is brilliant, charming, and silver-tongued. I’m guessing he’s the only Foundational Questions Institute grant awardee who also appears on the Pinterest Gorgeous Freaking Men page. Greene is the reigning spokesman for string theory, a theoretical framework proposing that one dimensional (also higher dimensions in later variants, e.g., “branes”) objects manifest different vibrational modes to make up all particles and forces of physics’ standard model. Though its proponents now discourage such usage, many call string theory the grand unification, the theory of everything. Since this includes gravity, string theorists also hold that string theory entails the elusive theory of quantum gravity. String theory has gotten a lot of press over the past few decades in theoretical physics and, through academic celebrities like Greene, in popular media.

XKCD

Several critics, some of whom once spent time in string theory research, regard it as not a theory at all. They see it as a mere formalism – a potential theory or family – very, very large family – of potential theories, all of which lack confirmable or falsifiable predictions. Lee Smolin, also brilliant, lacks some of Greene’s other attractions. Smolin is best known for his work in loop quantum gravity – roughly speaking, string theory’s main competitor. Smolin also had the admirable nerve to publicly state that, despite the Sokol hoax affair, sociologists have the right and duty to examine the practice of science. His sensibilities on that issue bring to bear on the practice of string theory.

Columbia University’s Peter Woit, like Smolin, is a highly vocal critic of string theory. Like Greene and Smolin, Woit is wicked sharp, but Woit’s tongue is more venom than silver. His barefisted blog, Not Even Wrong, takes its name from a statement Rudolf Peierls claimed Wolfgang Pauli had made about some grossly flawed theory that made no testable predictions.

The technical details of whether string theory is in fact a theory or whether string theorists have made testable predictions or can, in theory, ever make such predictions is great material that one could spend a few years reading full time. Start with the above mentioned authors and follow their references. Though my qualifications to comment are thin, it seems to me that string theory is at least in principle falsifiable, at least if you accept that failure to detect supersymmetry (required for strings) at the LHC or future accelerators over many attempts to do so.

But for this post I’m more interested in a related topic that Woit often covers – not the content of string theory but its practice and its relationship to society.

Regardless of whether it is a proper theory, through successful evangelism by the likes of Greene, string theory has gotten a grossly disproportionate amount of research funding. Is it the spoiled, attention-grabbing child of physics research? A spoiled child for several decades, says Woit – one that deliberately narrowed the research agenda to exclude rivals. What possibly better theory has never seen the light of day because its creator can’t get a university research position? Does string theory coerce and persuade by irrational methods and sleight of hand, as Feyerabend argued was Galileo’s style? Galileo happened to be right of course – at least on some major points.

Since Galileo’s time, the practice of science and its relationship to government, industry, and academic institutions has changed greatly. Gentleman scientists like Priestly, Boyle, Dalton and Darwin are replaced by foundation-funded university research and narrowly focused corporate science. After Kuhn – or misusing Kuhn – sociologists of science in the 1980s and 90s tried to knock science from its privileged position on the grounds that all science is tainted with cultural values and prejudices. These attacks included claims of white male bias and echoes of Eisenhower’s warnings about the “military industrial complex.”   String theory, since it holds no foreseeable military or industrial promise, would seem to have immunity from such charges of bias. I doubt Democrats like string more than Republicans.

Yet, as seen by Smolin and Woit, in string theory, Kuhn’s “relevant community” became the mob (see Lakatos on Kuhn/mob) – or perhaps a religion not separated from the state. Smolin and Woit point to several cult aspects of the string theory community. They find it to be cohesive, monolithic and high-walled – hard both to enter and to leave. It is hierarchical; a few leaders control the direction of the field while its initiates aim to protect the leaders from dissenting views.  There is an uncommon uniformity of views on open questions; and evidence is interpreted optimistically. On this view, string theorists yield to Bacon’s idols of the tribe, the cave, and the marketplace. Smolin cites the rarity of particle physicists outside of string theory to be invited to its conferences.

In The Trouble with Physics, Smolin details a particular example of community cohesiveness unbecoming to science. Smolin says even he was, for much of two decades, sucked into the belief that string theory had been proved finite. Only when he sought citations for a historical comparison of approaches in particle physics he was writing did he find that what he and everyone else assumed to have been proved long ago had no basis. He questioned peers, finding that they too had ignored vigorous skepticism and merely gone with the flow. As Smolin tells it, everyone “knew” that Stanley Mandelstam (UC Berkeley)  had proved string theory finite in its early days. Yet Mandelstam himself says he did not. I’m aware that there are other takes on the issue of finitude that may soften Smolin’s blow; but, in my view, his point on group cohesiveness and their indignation at being challenged still stand.

A telling example of the tendency for string theory to exclude rivals comes from a 2004 exchange on the sci.physics.strings Google group between Luboš Motl and Wolfgang Lerche of CERN, who does a lot of work on strings and branes. Motl pointed to Leonard Susskind’s then recent embrace of “landscapes,” a concept Susskind had dismissed before it became useful to string theory. To this Lerche replied:

“what I find irritating is that these ideas are out since the mid-80s… this work had been ignored (because it didn’t fit into the philosophy at the time) by the same people who now re-“invent” the landscape, appear in journals in this context and even seem to write books about it.  There had always been proponents of this idea, which is not new by any means.. . . the whole discussion could (and in fact should) have been taken place in 1986/87. The main thing what has changed since then is the mind of certain people, and what you now see is the Stanford propaganda machine working at its fullest.”

Can a science department in a respected institution like Stanford in fairness be called a propaganda machine? See my take on Mark Jacobson’s science for my vote. We now have evidence that science can withstand religion. The question for this century might be whether science, in the purse sense, can withstand science in the corporate, institutional, and academic sense.

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String theory cartoon courtesy of XKCD.

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I just discovered on Woit’s Not Even Wrong a mention of John Horgan’s coverage of Bayesian belief (previous post) applied to string theory. Horgan notes:

“In many cases, estimating the prior is just guesswork, allowing subjective factors to creep into your calculations. You might be guessing the probability of something that–unlike cancer—does not even exist, such as strings, multiverses, inflation or God. You might then cite dubious evidence to support your dubious belief. In this way, Bayes’ theorem can promote pseudoscience and superstition as well as reason.

Embedded in Bayes’ theorem is a moral message: If you aren’t scrupulous in seeking alternative explanations for your evidence, the evidence will just confirm what you already believe.”

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Science, God, and the White House

Back in the 80s I stumbled upon the book, Scientific Proof of the Existence of God Will Soon Be Announced by the White House!, by Franklin Jones, aka Frederick Jenkins, later Da Free John, later Adi Da Samraj. I bought it on the spot. Likely a typical 70s mystic charlatan, Jones nonetheless saw clearly our poor grasp of tools for seeking truth and saw how deep and misguided is our deference to authority. At least that’s how I took it.

Who’d expect a hippie mystic to be a keen philosopher of science. The book’s title, connecting science, church and state, shrewdly wraps four challenging ideas:

  1. That there can be such a thing as scientific proof of anything
  2. That there could be new findings about the existence of God
  3. That evidence for God could be in the realm of science
  4. That government should or could accredit a scientific theory

On the first point, few but the uneducated, TIME magazine, and the FDA think that proof is in the domain of science. Proof is deductive. It belongs to math, logic and analytic philosophy. Science uses evidence and induction to make inferences to the best explanation.

Accepting that strong evidence would suffice as proof, point number 2 is a bit trickier. Evidence of God’s existence can’t be ruled out a priori. God could be observable or detectable; we might see him or his consequences. An almighty god could easily have chosen to regularly show himself or to present unambiguous evidence. But Yahweh, at least in modern times, doesn’t play like that (A wicked and adulterous generation demands a sign but none will be given – Matthew 16:4). While believers often say no evidence would satisfy the atheist, I think a focused team could come up with rules for a demonstration that at least some nonbelievers would accept as sufficient evidence.

Barring any new observations that would constitute evidence, point number 3 is tough to tackle without wading deep into philosophy of science. To see why, consider the theory that God exists. Is it even a candidate for a scientific theory, as one WSJ writer thinks (Science Increasingly Makes the Case for God)? I.e., is it the content of a theory or the way it is handled by its advocates that makes the theory scientific? If the latter, it can be surprisingly hard to draw the line between scientific investigations and philosophical ones. Few scientists admit this line is so blurred, but how do string theorists, who make no confirmable or falsifiable predictions, defend that they are scientists? Their fondness for non-empirical theory confirmation puts them squarely in the ranks of the enlightenment empiricist, Bishop Berkeley of Cloyne (namesake of our fair university) who maintained that matter does not exist. Further, do social scientists make falsifiable predictions, or do they just continually adjust their theory to accommodate disconfirming evidence?

That aside, those who work in the God-theory space somehow just don’t seem to qualify as scientific – even the young-earth creationists trained in biology and geology. Their primary theory doesn’t seem to generate research and secondary theories to confirm or falsify. Their papers are aimed at the public, not peers – and mainly aim at disproving evolution. Can a scientific theory be primarily negative? Could plate-tectonics-is-wrong count as a proper scientific endeavor?

Gould held that God was simply outside the realm of science. But if we accept that the existence of God could be a valid topic of science, is it a good theory? Following Karl Popper, a scientific theory can withstand only a few false predictions. On that view the repeated failures of end-of-days predictions by Harold Camping and Herbert Armstrong might be sufficient to kill the theory of God’s existence. Or does their predictive failures simply exclude them from the community of competent practitioners?

Would NASA engineer, Edgar Whisenant be more credible at making predictions based on the theory of God’s existence? All his predictions of rapture also failed. He was accepted by the relevant community (“…in paradigm choice there is no standard higher than the assent of the relevant community” – Thomas Kuhn) since the Trinity Broadcast Network interrupted its normal programming to help watchers prepare. If a NASA engineer has insufficient scientific clout, how about our first scientist? Isaac Newton predicted, in Observations upon the Prophecies of Daniel and the Apocalypse of St. John, that the end would come in 2000 CE. Maybe Newton’s calculator had the millennium bug.

If we can’t reject the theory for any number of wrong predictions, might there be another basis for rejecting it? Some say absence of a clear mechanism is a good reason to reject theories. In the God theory, no one seems to have proposed a mechanism by which such a God could have arisen. Aquinas’s tortured teleology and Anselm’s ontological arguments still fail on this count. But it seems unfair to dismiss the theory of God’s existence on grounds of no clear mechanism, because we have long tolerated other theories deemed scientific with the same weakness. Gravity, for example.

Does assent of the relevant community grant scientific status to a theory, as Kuhn would have it? If so, who decides which community is the right one? Theologians spend far more time on Armageddon than do biologists and astrophysicists – and theologians are credentialed by their institutions. So why should Hawking and Dawkins get much air time on the matter? Once we’ve identified a relevant community, who gets to participate in its consensus?

This draws in point number 4, above. Should government or the White House have any more claim to a scientific pronouncement than the Council of Bishops? If not, what are we to think of the pronouncements by Al Gore and Jerry Brown that the science of climate is settled? Should they have more clout on the matter than Pope Francis (who, interestingly, has now made similar pronouncements)?

If God is outside the realm of science, should science be outside the jurisdiction of government? What do we make of President Obama’s endorsement of “calling out climate change deniers, one by one”? You don’t have to be Franklin Jones or Da Free John to see signs here of government using the tools of religion (persecution, systematic effort to censure and alienate dissenters) in the name of science. Is it a stretch to see a connection to Jean Bodin, late 16th century French jurist, who argued that only witches deny the existence of witches?

Can you make a meaningful distinction between our government’s pronouncements on the truth or settledness of the climate theory (as opposed to government’s role in addressing it) and the Kremlin’s 1948 pronouncement that only Lamarckian inheritance would be taught, and their call for all geneticists to denounce Mendelian inheritance? Is it scientific behavior for a majority in a relevant community to coerce dissenters?

In trying to draw a distinction between UN and US coercion on climate science and Lysenkoism, some might offer that we (we moderns or we Americans) are somehow different – that only under regimes like Lenin’s and Hitler’s does science get so distorted. In thinking this, it’s probably good to remember that Hitler’s eugenics was born right here, and flourished in the 20th century. It had nearly full academic support in America, including Stanford and Harvard. That is, to use Al Gore’s words, the science was settled. California, always a trendsetter, by the early 1920s, claimed 80% of America’s forced sterilizations. Charles Goethe, founder of Sacramento State University, after visiting Hitler’s Germany in 1934 bragged to a fellow California eugenicist about their program’s influence on Hitler.

If the era of eugenics seems too distant to be relevant to the issue of climate science/politics, consider that living Stanford scientist, Paul Ehrlich, who endorsed compulsory abortion in the 70s, has had a foot in both camps.

As crackpots go, Da Free John was rather harmless.

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“Indeed, it has been concluded that compulsory population-control laws, even including laws requiring compulsory abortion, could be sustained under the existing Constitution if the population crisis became sufficiently severe to endanger the society.” – Ehrlich, Holdren and Ehrlich, EcoScience, 3rd edn, 1977, p. 837

“You will be interested to know that your work has played a powerful part in shaping the opinions of the group of intellectuals who are behind Hitler in this epoch-making program.” – Charles Goethe, letter to Edwin Black, 1934

 

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